Drugs With Tirzepatide Linked to Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)
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We created this Zepbound and Mounjaro Eye Side Effect NAION Information Page soon after a medical article was published on August 11, 2025, by JAMA Network Open that provided some new important evidence regarding an increased risk of non-arteritic ischemic optic neuropathy, or NAION, with Mounjaro in diabetes patients.
Previously, we learned that the FDA has been investigating “potential signals” of the eye side effect NAION with Mounjaro and Zepbound — the active ingredient is tirzepatide for both medications — as well as other glucagon-like peptide-1 (GLP-1) receptor agonist drugs, collectively referred to as GLP-1 RAs. To learn more about what we previously knew about how Zepbound and Mounjaro might be associated with the eye side effect NAION, you can read our June 2025 Drug Injury Watch blog post, “Current FDA Safety Investigation: NAION With Mounjaro, Zepbound, and Other GLP-1 RAs”.
The August 2025 JAMA Network Open article, “Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes“, provided more evidence for an increased risk of non-arteritic ischemic optic neuropathy, or NAION, with Ozempic (semaglutide) or Mounjaro (tirzepatide) in diabetes patients.
Before we get into what important evidence this recent medical article provided about NAION being associated with Mounjaro when used by diabetes patients, we point out that about a year ago, back in July 2024, we created this Drug Injury Law webpage about NAION linked to Ozempic, Rybelsus, and Wegovy: “Eye-related Side Effects of Ozempic, Wegovy, and Rybelsus With Vision Loss — Drugs With Semaglutide Linked to Nonarteritic Anterior Ischemic Optic Neuropathy (NAION)”.
Now, in relevant part, here are some of the points from the August 2025 medical article regarding the Mounjaro eye side effect NAION in diabetes patients:
- Nonarteritic anterior ischemic optic neuropathy (NAION) is characterized by loss of vision due to decreased blood flow to the optic nerve.
- The medical researchers compared Mounjaro (tirzepatide) with other antidiabetic medications for the associated risk of NAION in patients with type 2 diabetes who had no prior diagnosis of any eye disorder.
- Mounjaro (tirzepatide) is a newer and more potent GLP-RA to treat type 2 diabetes and obesity.
- In a population of patients with type 2 diabetes who had no prior diagnosis of eye diseases, this cohort study found that when Mounjaro (tirzepatide) was compared with other antidiabetic medications, there was an increased risk of NAION.
Besides Mounjaro, as we stated earlier, there is a second GLP-1RA drug that contains the active ingredient tirzepatide, Zepbound. That medication is used for obesity and weight loss purposes. There is some evidence that the NAION eye side effect may be associated with Zepbound, given that both drugs have the active ingredient tirzepatide.
Of course, we will continue to monitor relevant medical journals for additional studies concerning the association of NAION with Mounjaro and Zepbound. And we will watch for the results of the current FDA investigation, mentioned above, that involves the eye side effect NAION with Mounjaro and Zepbound.
Free Case Evaluation for Zepbound or Mounjaro Eye Side Effect NAION
We encourage you to submit a Zepbound / Mounjaro Eye Side Effect NAION Case Evaluation Form online – it is free, confidential, and there is no obligation. Or, if you prefer, call 910-256-2971 to speak directly to attorney Tom Lamb about a possible Zepbound or Mounjaro drug injury lawsuit. Either way, you will get Mr. Lamb’s impressions – not an intake person, a paralegal, or some other lawyer – about your case based on his over 20 years of experience handling drug injury cases.
Most Recent Articles About Zepbound and Mounjaro Eye Side Effect NAION With Vision Loss
Ozempic and Mounjaro Increased Risk of NAION More Than Other Diabetes Drugs
A 2025 medical study considered whether treatment with either Ozempic (semaglutide) or Mounjaro (tirzepatide) is associated with an increased risk of non-arteritic anterior ischemic optic neuropathy (NAION) when compared to other antidiabetic medications. The researchers concluded that there is an Ozempic and Mounjaro increased risk of NAION.
A new medical article published in August 2025 had an important drug safety bottom-line statement: “In this study of patients with type 2 diabetes who had no prior eye disorders, patients prescribed [Ozempic (semaglutide)] or [Mounjaro (tirzepatide)] had an increased risk of NAION…”.
To read more of this article, click below:
From the Discussion part of this recent medical journal article published August 11, 2025, online by JAMA Network Open, “Semaglutide or Tirzepatide and Optic Nerve and Visual Pathway Disorders in Type 2 Diabetes“:
In a population of patients with type 2 diabetes who had no prior diagnosis of eye diseases, this cohort study found that semaglutide [(Ozempic)] or tirzepatide [(Mounjaro)] compared with other antidiabetic medications was associated with a differential risk of optic nerve and visual pathways, including increased risk of NAION and other optic nerve disorders, but not optic neuritis, papilledema, optic atrophy, or optic disc orders. Cumulative incidence curves began to diverge immediately after medication initiation and continued to separate thereafter.
Related to this Ozempic and Mounjaro increased risk of NAION finding, we point out that there are additional drugs not used for diabetes but for obesity and weight loss purposes that contain semaglutide (Wegovy, Rybelsus) or tirzepatide (Zepbound). As we have covered in earlier articles, there is some evidence that the NAION eye-related side effect is associated with those additional drugs, too.
We will continue to follow the Ozempic and Mounjaro increased risk of NAION drug safety issue, as well as whether the two other semaglutide-containing drugs (Wegovy, Rybelsus) and the one other tirzepatide-containing drug (Zepbound) are associated with an increased risk of NAION.
[Read the article in full at source]
NAION With Tirzepatide-containing Drugs Mounjaro and Zepbound
The possible connection of NAION with tirzepatide-containing drugs Mounjaro and Zepbound is being investigated by the FDA, according to “October – December 2024 | Potential Signals of Serious Risks/New Safety Information Identified by the FDA Adverse Event Reporting System (FAERS)”.
During the past year, we have written about the vision loss side effect NAION (non-arteritic anterior ischemic optic neuropathy) being linked to semaglutide-containing drugs Ozempic, Rybelsus, and Wegovy. This is our first article about the possible connection of NAION with tirzepatide-containing drugs Mounjaro and Zepbound.
We will watch for developments concerning the possible connection of NAION with tirzepatide-containing drugs Mounjaro and Zepbound.
If you have developed NAION with Mounjaro or Zepbound, there might be a drug injury lawsuit against the responsible pharmaceutical company. Please don’t hesitate to contact us if you are interested in such a case.
[Read the article in full at source]