We have written several times previously about meningioma with Depo-Provera use, and we are investigating drug injury lawsuits for women who have been diagnosed with intracranial meningioma seeking legal compensation from the responsible pharmaceutical companies. Related to both of these are whether there are any additional risk factors for developing meningioma with Depo-Provera use.
A relatively new medical journal article, “Depot Medroxyprogesterone Acetate and Risk of Meningioma in the US”, pointed out two sets of women who are more likely to develop meningioma with Depo-Provera use:
(1) Women with at least 4 years of Depo-Provera use; and,
(2) Women who started their Depo-Provera injections after age 31.
As such, those two factors can be viewed as additional risk factors for meningioma side effects associated with Depo-Provera (depot medroxyprogesterone acetate).
That article reporting on a medical study of Depo-Provera meningioma cases in the US can be found in the November 2025 print edition of JAMA Neurology.
From the Results part of this medical journal article’s Abstract:
Use of [Depo-Provera (depot medroxyprogesterone acetate)] had a relative risk of 2.43 (95% CI, 1.77-3.33) for meningioma diagnosis compared with controls. Notably, this risk was confined for patients with longer than 4 years of exposure or starting the prescription at ages older than 31 years.
We point out that these meningioma with Depo-Provera use drug injury lawsuits will not be filed against the women’s doctors who prescribed the Depo-Provera injections. This is because the Depo-Provera drug label in the US does not have any warnings about the increased risk of intracranial meningioma.
A woman diagnosed with an intracranial meningioma while using Depo-Provera or after she stopped using Depo-Provera can submit an Online Case Evaluation Form for a possible Depo-Provera drug injury lawsuit. Alternatively, you can call 910-256-2971 to speak with attorney Tom Lamb about your meningioma with Depo-Provera use situation.
[Read the article in full at Drug Injury Watch]Depo-Provera Contraceptive Injection
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