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Law Offices of Thomas J. Lamb

Prilosec / Prevacid / Nexium Federal Court MDL For Kidney Injury Cases

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In August 2017 the United States Judicial Panel on Multidistrict Litigation (JPML) granted a second motion for centralization or consolidation of federal court lawsuits brought by plaintiffs in proton-pump inhibitors (PPIs) cases alleging kidney injury.

In more detail, the JPML established IN RE: PROTON-PUMP INHIBITOR PRODUCTS LIABILITY LITIGATION (NO. II) – MDL No. 2789. From the JPML’s Transfer Order filed on August 2, 2017 we get these details:

In the complaints in these 161 personal injury and wrongful death actions, plaintiffs allege that as a result of taking one or more proton-pump inhibitors (PPIs), they or their decedents suffered kidney injury (e.g., chronic kidney disease (CKD), acute interstitial nephritis, end stage renal disease, or kidney failure). Plaintiffs allege that defendants failed to adequately warn of the negative effects and risks associated with PPIs….

Notably, during this second time around only one drug company, Takeda. was still opposed to the creation of any PPIs federal court MDL. But the JPML was not convinced by Takeda’s various arguments in opposition, as seen from this excerpt from the Transfer Order:

And, although it is true that AstraZeneca is sued in far more actions than Takeda, a significant number of actions are “mixed use” cases in which the plaintiffs allege use of more than one PPI, and sue Takeda and one or more other PPI manufacturers, including AstraZeneca. The prospect of additional cases against Takeda does not seem far-fetched [10]. Given these circumstances, including the seemingly indivisible nature of plaintiffs’ alleged injuries in the “mixed use” cases, we decline to carve out from the MDL cases or claims against Takeda. [footnotes omitted]

Lastly, this point – which may have been a factor for the JPML when ruling this time on the Prilosec / Prevacid / Nexium federal court MDL consolidation – was mentioned in a footnote for the August 2017 Transfer Order: “The variety of alleged kidney injuries arguably has diminished, as most plaintiffs allege that they suffer from [chronic kidney disease (CKD)]….”

We continue to monitor legal and medical developments regarding the drug injury aspects of Nexium, Prevacid, and Prilosec.

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Prevacid, Nexium, And Prilosec Linked To Risk Of Chronic Kidney Damage

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A recent medical study done by medical researchers in St. Louis, Missouri indicates that more than half of those patients who develop chronic kidney damage (CKD) while using proton pump inhibitors (PPIs) heartburn drugs and acid reflux medicines do not experience acute kidney problems before their CKD diagnosis.

These researchers published their findings in this February 2107 article, “Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury”, published in the Kidney International medical journal.

A February 22, 2017 ScienceDaily news report, “Popular heartburn drugs linked to gradual yet ‘silent’ kidney damage”, provides a good analysis of this recent safety study concerning Nexium, Prevacid, Prilosec, and other PPI heartburn drugs and acid reflux medicines.

From that ScienceDaily news report we get this information:

The onset of acute kidney problems is not a reliable warning sign for clinicians to detect a decline in kidney function among patients taking proton pump inhibitors, said Ziyad Al-Aly, MD, the study’s senior author and an assistant professor of medicine at Washington University School of Medicine. “Our results indicate kidney problems can develop silently and gradually over time, eroding kidney function and leading to long-term kidney damage or even renal failure….  [M]ore than half of the cases of chronic kidney damage and end-stage renal disease associated with PPI use occurred in people without acute kidney problems….

We are currently investigating possible drug injury lawsuits against the responsible pharmaceutical companies for people who have developed any of the kidney-related medical problems listed above.

Of course, we will continue to monitor the medical literature for developments concerning serious kidney-related side effects of popular heartburn drugs and acid reflux medicines like Nexium, Prilosec, and Prevacid.

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Long-Term Use Of Prevacid, Prilosec, and Nexium May Lead To Strokes

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In November 2016 we learned about a new study that suggests these popular category heartburn medications, known as proton pump inhibitors (PPIs), may increase the risk of ischemic strokes.

From a press release from the American Heart Association, “Popular heartburn medication may increase ischemic stroke risk”, we get the following facts:

A popular group of antacids known as proton pump inhibitors, or PPIs, used to reduce stomach acid and treat heartburn may increase the risk of ischemic stroke, according to preliminary research presented at the American Heart Association’s Scientific Sessions 2016….

Ischemic stroke, the most common type of stroke, is caused by clots blocking blood flow to or in the brain.

… Researchers determined if the stroke occurred while patients were using 1 of 4 PPIs: omeprazole (Prilosec), pantoprazole (Protonix), lansoprazole (Prevacid) and esomeprazole (Nexium).

For ischemic stroke, researchers found:

Overall stroke risk increased by 21 percent when patients were taking a PPI.

At the lowest doses of the PPIs, there was slight or no increased stroke risk.

At the highest dose for these 4 PPI’s, stroke risk increased from 30 percent for lansoprazole (Prevacid) to 94 percent for pantoprazole (Protonix).

We will continue to monitor the various side effects that have been associated with the use of Nexium, Prilosec, and Prevacid, as well as proton pump inhibitors (PPIs) heartburn drugs and acid reflux medicines.

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Viagra, Nexium, And Invokana: Drug Injury Lawsuits Report: Summer 2016

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We are currently investigating possible drug injury lawsuits against the responsible pharmaceutical companies for patients who used the drugs listed below and developed certain side effects.

(1) Erectile Dysfunction (ED) Pills, Benign Prostatic Hyperplasia (BPH) Medicines, and Pulmonary Arterial Hypertension (PAH) Medications in the Phosphodiesterase 5 (PDE-5) Inhibitors Class of Drugs

Adcirca (tadalafil) — Eli Lilly and Company
Cialis (tadalafil) — Eli Lilly and Company
Levitra (vardenafil hydrochloride) — GlaxoSmithKline
Revatio (sildenafil citrate) — Pfizer
Staxyn (vardenafil hydrochloride) — GlaxoSmithKline
Stendra (avanafil) — Vivus and Auxilium Pharmaceuticals
Viagra (sildenafil citrate) — Pfizer

These various prescription drug products have been linked to malignant melanoma skin cancer (but not basal or squamous cell skin cancers).

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(2) Heartburn Medicines and Acid Reflux Pills like Prevacid, Prilosec, and Nexium in the Proton Pump Inhibitors (PPIs) Class of Drugs

Nexium (esomeprazole magnesium) [prescription drug] == AstraZeneca LP
Nexium 24HR (esomeprazole magnesium) [over-the-counter] — Pfizer Consumer Healthcare
Prilosec (omeprazole) [prescription drug] — AstraZeneca LP
Prilosec OTC (omeprazole) [over-the-counter] — Procter & Gamble Manufacturing Co.
Prevacid (lansoprazole) [prescription drug] — Takeda Pharmaceuticals America, Inc.
Prevacid 24 HR (lansoprazole) [over-the-counter] — Novartis Consumer Health, Inc.

The use of these proton pump inhibitors (PPIs) can result in an increased risk of developing Acute Interstitial Nephritis (AIN) as well as other types of kidney disease and kidney injury.

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(3) Diabetes Medicines in the Sodium-Glucose Co-Transporter-2 (SGLT2) Inhibitors Class of Drugs

Invokana (canagliflozin) — Janssen Pharmaceuticals
Invokamet (canagliflozin and metformin) — Janssen Pharmaceuticals
Farxiga (dapagliflozin) — AstraZeneca Pharmaceuticals
Xigduo XR (dapagliflozin and metformin extended-release) — AstraZeneca Pharmaceuticals
Jardiance (empagliflozin) — Boehringer Ingelheim Pharmaceuticals
Glyxambi (empagliflozin and linagliptin) — Boehringer Ingelheim Pharmaceuticals
Synjardy (empagliflozin and metformin hydrochloride) — Boehringer Ingelheim Pharmaceuticals and Eli Lilly and Company

These drug injury lawsuits primarily involve the side effects ketoacidosis, kidney problems, and severe infections.

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These three types of drug injury cases are starting to gain some momentum in terms of the number of lawsuits filed against the responsible pharmaceutical companies in courts across the country.

We have been representing patients and their family in drug injury lawsuits for the past 16 years and this is our main practice area. Let us know if we can help you.

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Viagra / Cialis / Levitra
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Nexium / Prevacid / Prilosec

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Invokana / Farxiga / Jardiance

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Heartburn Medication Nexium Might Cause Kidney-Related Side Effects

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There is mounting medical evidence that the use of Prilosec, Prevacid, and Nexium results in an increased risk of developing chronic kidney disease (CKD) as well as CKD disease progression and end-stage renal disease (ESRD). Further, the latest medical study shows that with greater use over time of heartburn pills in the proton pump inhibitors (PPIs) class of drugs, comes a greater risk of developing these serious side effects.

This medical journal article, “Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD”, published April 14, 2016 in the Journal of the American Society of Nephrology (JASN), reports on researchers’ analysis of national Veterans Administration databases to investigate this still emerging drug safety issue involving Nexium and other PPIs. From the Abstract for this April 2016 JASN article, we get this brief overview of their findings:

The association between proton pump inhibitors (PPI) use and risk of acute interstitial nephritis has been described. However, whether exposure to PPI associates with incident [chronic kidney disease (CKD)], CKD progression, or [end-stage renal disease (ESRD)] is not known…. Our results suggest that PPI exposure associates with increased risk of incident CKD, CKD progression, and ESRD.

And a few months ago, similar findings — from researchers at The Johns Hopkins University, Yale University School of Medicine, and two other institutions — were reported in this “Original Investigation” article, “Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease”, which was initially published in January 2016 by the medical journal JAMA Internal Medicine.

Now we shift our focus from the long-term, chronic kidney disease (CKD) side effect possibly associated with heartburn and acid reflux drugs such as Nexium, Prevacid, and Prilosec, to the more immediate, acute renal / kidney injury side effect, of which there is an apparent increased risk.

About a year ago, back in April 2015, this article, “Proton pump inhibitors and the risk of acute kidney injury in older patients: a population-based cohort study”, was published online at the CMAJ Open site.

To be clear, we are not suggesting that anyone stop using proton pump inhibitors based on the findings of these three medical studies regarding drugs like Nexium, Prevacid, and Prilosec. Rather, people who use these PPIs regularly, whether by prescription or over-the-counter, might want to talk with their doctor about whether they really need to use one of these drugs in view of the possible links with chronic kidney disease and acute renal or kidney injury.

We will continue to monitor the medical literature for further developments regarding the kidney-related side effects of Nexium, Prevacid, Prilosec, and other heartburn medications (prescription and OTC) in the PPI class of drugs.

[Read this article in full at original source]

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Law Offices of Thomas J. Lamb, P.A.
1908 Eastwood Road, Suite 225
Wilmington, North Carolina 28403
910-256-2971 | 800-426-9535
TJL@LambLawOffice.com